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Wounds & HBOT (Study 2)

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Research for Inquiring Minds

Hyperbaric Oxygen Therapy as an Anti-Infective Agent

Çimşit, Maide; Uzun, Günalp; Yıldız, Şenol
Expert Review of Anti-Infective Therapy, Vol. 7, No. 8, October 2009 , pp.1015-1026(12)

Hyperbaric oxygen therapy (HBOT) involves inhalation of 100% oxygen at supra-atmospheric ambient pressure. HBOT is used as either a primary or adjunctive treatment in the management of infections such as gas gangrene, necrotizing fasciitis, diabetic foot infections, refractory osteomyelitis, neurosurgical infections and fungal infections. HBOT acts as a bactericidal/bacteriostatic agent against anerobic bacteria by increasing the formation of free oxygen radicals. HBOT restores the bacterial-killing capacity of leukocytes in hypoxic wounds by increasing tissue oxygen tensions. In addition, HBOT acts synergistically with a number of antibiotics. This article reviews the anti-infective effects of HBOT and the use of HBOT in the treatment of certain infectious diseases.