Hyperbaric therapy is typically used to treat burns to the hands, face or groin area, or for deep second-degree and third-degree burns that cover more than 20% of the patient's body. The basic problems in repair of burns include susceptibility to infection, prolonged healing, and excessive scarring. HBOT promotes vasoconstriction, decreasing inflow into tissue and edema. HBOT promotes reduction in fluid requirements, less conversion of partial to full thickness injury, preservation of marginally viable tissue, improved microcirculation, reduction in edema, faster epithelialization, less inflammatory response, enhancement of PMN killing, preservation of tissue creatine phosphate, adenosine triphosphate, and decreased wound lactate.