Radiation injury is the damage to the soft tissue and bone following radiation therapy. There are early and late effects, occurring weeks and years after the radiation caused by ischemia, interruption of the blood supply and direct cells damage, which are sensitive to radiation. Hyperbaric treatment allows more oxygen to reach these damaged areas and helps prevent tissue from dying for lack of blood and oxygen flow. It is most often used in the head and neck areas.

HBOT promotes angiogenesis and hyperoxygenation to the radiated affected tissues. Increasing the oxygen content to the surrounding tissues markedly increases the overall oxygen gradient between these tissues and the central hypoxic area. The increased oxygen gradient is the essential catalytic factor for angiogenesis.